Rabbit anti-Human, Mouse MAL2 Polyclonal Antibody | anti-MAL2 antibody

MAL2 Antibody

Cat. Num. AAA9629358

• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: MAL2; Polyclonal Antibody; MAL2 Antibody; MAL 2; MAL proteolipid protein 2; Mal; T cell differentiation protein 2; mal2; MAL2_HUMAN; Protein MAL2; anti-MAL2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: MAL2 Antibody detects endogenous levels of total MAL2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-MAL2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the MAL family.
• Subunit Structure: Interacts with TPD52L2.
• Tissue Specificity: Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.
• Function: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
• Note: Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized Hep-G2 cells, distributed to the perinuclear region.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-MAL2 antibody

Cell membrane; Multi-pass membrane protein; Apical cell membrane; Endomembrane system; Cytoplasm; Perinuclear region; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 16418397
• NCBI GeneID: 114569
• NCBI Accession #: NP_443118.1
• NCBI GenBank Nucleotide #: NM_052886.2
• UniProt Accession #: Q969L2; Q6ZMD9; B2R520
• Molecular Weight: 19,125 Da
• NCBI Official Full Name: protein MAL2
• NCBI Official Synonym Full Names: mal, T-cell differentiation protein 2 (gene/pseudogene)
• NCBI Official Symbol: MAL2
• NCBI Protein Information: protein MAL2
• UniProt Protein Name: Protein MAL2
• Protein Family: Molybdenum cofactor sulfurase
• UniProt Gene Name: MAL2
• UniProt Entry Name: MAL2_HUMAN

NCBI Description

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]

Uniprot Description

MAL2: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. Belongs to the MAL family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q23

Cellular Component: perinuclear region of cytoplasm; apical plasma membrane; integral to membrane; endomembrane system; lipid raft

Molecular Function: protein binding