Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis tissue using MBS1499103 at dilution of 1:100)
Rabbit anti-Human MAEL Polyclonal Antibody | anti-MAEL antibody
MAEL Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis tissue using MBS1499103 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis tissue using MBS1499103 at dilution of 1:100)
NCBI and Uniprot Product Information
Uniprot Description
MAEL: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage. Belongs to the maelstrom family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 1q24.1
Cellular Component: autosome; chromatin; cytoplasm; nucleus; perinuclear region of cytoplasm; XY body
Molecular Function: sequence-specific DNA binding
Biological Process: cell differentiation; cell morphogenesis; DNA damage response, signal transduction resulting in induction of apoptosis; DNA methylation during gametogenesis; fertilization; gene expression; male meiosis; multicellular organismal development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of organ growth; RNA-mediated gene silencing; spermatogenesis; synapsis
Research Articles on MAEL
Similar Products
Product Notes
The MAEL mael (Catalog #AAA1499103) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MAEL Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MAEL can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the MAEL mael for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MAEL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
