Rabbit anti-Human Macrophage Derived Chemokine Polyclonal Antibody | anti-MDC antibody
Macrophage Derived Chemokine (MDC, MDC(1-69), A-152E5.1, ABCD-1, CC Chemokine STCP-1, C-C Motif Chemokine 22, Chemokine (C-C Motif) Ligand 22, CCL22, DC/B-CK, MGC34554, Small Inducible Cytokine A22, SCYA22, Stimulated T-cell Chemotactic Protein 1, STCP-1)
FLISA: 0.5ug/ml
WB: 0.1-0.2ug/ml
Applications are based on unconjugated antibody.
NCBI and Uniprot Product Information
NCBI Description
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Jul 2008]
Uniprot Description
CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted; Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: extracellular space; extracellular region
Molecular Function: chemokine activity
Biological Process: cell-cell signaling; response to virus; immune response; signal transduction; inflammatory response; chemotaxis