Rabbit anti-Human Macrophage Derived Chemokine Polyclonal Antibody | anti-MDC antibody

Macrophage Derived Chemokine (MDC, MDC(1-69), A-152E5.1, ABCD-1, CC Chemokine STCP-1, C-C Motif Chemokine 22, Chemokine (C-C Motif) Ligand 22, CCL22, DC/B-CK, MGC34554, Small Inducible Cytokine A22, SCYA22, Stimulated T-cell Chemotactic Protein 1, STCP-1)

Cat. Num. AAA6485791

• Gene Names: CCL22; MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1
• Reactivity: Human
• Applications: Functional Assay, ELISA, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: Macrophage Derived Chemokine; Polyclonal Antibody; Macrophage Derived Chemokine (MDC; MDC(1-69); A-152E5.1; ABCD-1; CC Chemokine STCP-1; C-C Motif Chemokine 22; Chemokine (C-C Motif) Ligand 22; CCL22; DC/B-CK; MGC34554; Small Inducible Cytokine A22; SCYA22; Stimulated T-cell Chemotactic Protein 1; STCP-1); anti-MDC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MDC.
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-MDC antibody: Functional Assay, ELISA (EIA), Western Blot (WB)
• Application Notes: Functional Assay: 5-7ug/ml; ELISA: 0.5ug/ml; WB: 0.1-0.2ug/ml; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human MDC.
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-MDC antibody

Antibodies; Growth Factors; Cytokines

References

1. Imai, T. et al. (1998). Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4*. J. Biol. Chem. 273: 1764-1768. 2. Horikawa, T. et al. (2002). IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis. Int. Immunol. 14: 767-773.

NCBI and Uniprot Product Information

• NCBI GI #: 1931581
• NCBI GeneID: 6367
• UniProt Accession #: O00626; A0N0Q6; B2R4W2
• Molecular Weight: 10,625 Da
• NCBI Official Full Name: macrophage-derived chemokine
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 22
• NCBI Official Symbol: CCL22
• NCBI Official Synonym Symbols: MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1
• NCBI Protein Information: C-C motif chemokine 22; MDC(1-69); CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine su
• UniProt Protein Name: C-C motif chemokine 22
• UniProt Gene Name: CCL22
• UniProt Synonym Gene Names: MDC; SCYA22
• UniProt Entry Name: CCL22_HUMAN

NCBI Description

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Jul 2008]

Uniprot Description

CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: cell-cell signaling; response to virus; immune response; signal transduction; inflammatory response; chemotaxis