Rabbit M11P Polyclonal Antibody | anti-M11P antibody
Rabbit anti-Saccharomyces cerevisiae killer virus M1 (ScV-M1)(Saccharomyces cerevisiae virus M1) M11P Polyclonal Antibody
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH7.4
2. 1mL preimmune serum (negative control)
3. 10mg rabbit polyclonal antibody purified by Protein A/G.
2. Antibody titer > 1: 64,000 confirmed by ELISA
3. Western Blot positive for the immunogen protein (Not applicable for synthetic peptide).
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NCBI and Uniprot Product Information
Uniprot Description
Function: Ionophoric toxin secreted by an infected host and lethal to non-infected sensitive strains. Cell killing is achieved in a receptor-mediated process, requiring initial toxin binding to a cell wall (1->6)-beta-D-glucan and, probably, subsequent transfer to a plasma membrane receptor. K1 toxin disrupts the cell by creating a pore across the target cell membrane. Ref.4
Subunit structure: The secreted toxin contains alpha and beta chains that are linked by three disulfide bonds.
Subcellular location: Secreted. Host membrane; Multi-pass membrane protein
Potential. Note: Pore-forming in target cell
Probable.
Miscellaneous: The killer phenotype requires the presence of two different dsRNA viruses: an L-A helper virus and the toxin-coding (M) killer virus. Killer strains of S.cerevisiae producing the toxin K1 kill sensitive cells but are resistant to their own toxin. The gamma and delta chains may play a role, on there own or as part of the protoxin, in the self-protection of the virus-infected killer yeast (toxin immunity).