Western Blot (WB)
(WB Suggested Anti-LYZ AntibodyTitration: 1.0 ug/mlPositive Control: ACHN Whole Cell)
Rabbit LYZ Polyclonal Antibody | anti-LYZ antibody
LYZ antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-LYZ AntibodyTitration: 1.0 ug/mlPositive Control: ACHN Whole Cell)
Western Blot (WB)
(WB Suggested Anti-LYZ AntibodyTitration: 1.0 ug/mlPositive Control: ACHN Whole Cell)
Target Description: LYZ is a human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the anti-microbial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. Missense mutations in LYZ have been identified in heritable renal amyloidosis.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
Uniprot Description
LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family.
Protein type: EC 3.2.1.17; Endoplasmic reticulum; Secreted, signal peptide; Vesicle; Secreted; Hydrolase
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: extracellular space; extracellular region
Molecular Function: identical protein binding; lysozyme activity
Biological Process: retinal homeostasis; metabolic process; cytolysis; defense response to bacterium; inflammatory response
Disease: Amyloidosis, Familial Visceral
Research Articles on LYZ
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Product Notes
The LYZ lyz (Catalog #AAA3214732) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LYZ antibody - C-terminal region reacts with Cow, Guinea Pig, Horse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's LYZ can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the LYZ lyz for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: HLSCSALLQD NIADAVACAK RVVRDPQGIR AWVAWRNRCQ NRDVRQYVQG. It is sometimes possible for the material contained within the vial of "LYZ, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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