Western Blot (WB)
(Western Blot analysis of LYAR in LOVO cell lysate using LYAR Rabbit pAb at dilution 1/1000)
Rabbit anti-Human LYAR Polyclonal Antibody | anti-LYAR antibody
LYAR Rabbit pAb
Gene Names
LYAR; ZLYAR; ZC2HC2
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Affinity purified
Synonyms
LYAR; Polyclonal Antibody; LYAR Rabbit pAb; Ly1 antibody reactive; ZLYAR; ZC2HC2; anti-LYAR antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purified
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-LYAR antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
WB: 1:1000-1:5000
IHC-P: 1:50-1:200
IHC-P: 1:50-1:200
Immunogen
Fusion protein of human LYAR
Conjugation
Unconjugated
Modification
Unmodified
Preparation and Storage
Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.
Western Blot (WB)
(Western Blot analysis of LYAR in LOVO cell lysate using LYAR Rabbit pAb at dilution 1/1000)
Western Blot (WB)
(Western Blot analysis of LYAR in LOVO cell lysate using LYAR Rabbit pAb at dilution 1/1000)
Immunohistochemistry (IHC)
(Immunohistochemistry of LYAR in paraffin-embedded Human gastric cancer tissue using LYAR Rabbit pAb at dilution 1/140. Predicted cell location: Nucleus)
Immunohistochemistry (IHC)
(Immunohistochemistry of LYAR in paraffin-embedded Human gastric cancer tissue using LYAR Rabbit pAb at dilution 1/140. Predicted cell location: Nucleus)
Related Product Information for anti-LYAR antibody
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43,615 Da
NCBI Official Full Name
cell growth-regulating nucleolar protein
NCBI Official Synonym Full Names
Ly1 antibody reactive
NCBI Official Symbol
LYAR
NCBI Official Synonym Symbols
ZLYAR; ZC2HC2
NCBI Protein Information
cell growth-regulating nucleolar protein; Ly1 antibody reactive homolog
UniProt Protein Name
Cell growth-regulating nucleolar protein
Protein Family
UniProt Gene Name
LYAR
UniProt Entry Name
LYAR_HUMAN
Uniprot Description
LYAR:
Protein type: Nucleolus; Unknown function
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: nucleolus; nucleus
Molecular Function: protein binding; metal ion binding
Similar Products
Product Notes
The LYAR lyar (Catalog #AAA4759406) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LYAR Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LYAR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:1000-1:5000 IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the LYAR lyar for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LYAR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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