Rabbit anti-Mouse. LTBP1 Polyclonal Antibody | anti-LTBP1 antibody

LTBP1, CT (Latent-transforming Growth Factor beta Binding Protein 1, LTBP-1, MGC163161, Transforming Growth Factor beta-1 Binding Protein 1, TGF-beta1-BP-1)

Cat. Num. AAA627057

• Gene Names: LTBP1; MGC163161
• Reactivity: Mouse.
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Purified by ammonium sulfate precipitation
• Synonyms: LTBP1; Polyclonal Antibody; CT (Latent-transforming Growth Factor beta Binding Protein 1; LTBP-1; MGC163161; Transforming Growth Factor beta-1 Binding Protein 1; TGF-beta1-BP-1); Anti -LTBP1; anti-LTBP1 antibody

• Host: Rabbit
• Reactivity: Mouse.
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human LTBP1.
• Purity/Purification: Purified by ammonium sulfate precipitation
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.
• Concentration: 1.89 mg/mL (varies by lot)

• Applicable Applications for anti-LTBP1 antibody: Suitable for use in ELISA, Western Blot, and Immunohistochemistry . Other applications have not been tested.
• Application Notes: Western Blot: 1:1000; Immunohistochemistry (FFPE): 1:10-1:50; ; Optimal dilutions to be determined by the researcher.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1493-1525 in the C-terminal region of human LTBP1.
• Preparation and Storage: May be stored at 4°C for short term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse bladder tissue lysates (35ug/lane) using MBS627057. This demonstrates that MBS627057 detected the LTBP1 protein (arrow).)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with MBS627057, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS627057 for immunohistochemistry.)

Related Product Information for anti-LTBP1 antibody

LTBP1 may be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. This protein may play critical roles in controlling and directing the activity of TGFB1, and it may have a structural role in the extra cellular matrix (ECM).

Product Categories/Family for anti-LTBP1 antibody

Antibodies; Abs to Growth Factors; Cytokines

References

1.Olofsson A., J. Biol. Chem. 270:31294-31297(1995). 2.Kanzaki T., Cell 61:1051-1061(1990). 3.Isogai Z., J. Biol. Chem. 278:2750-2757(2003). 4.Oklu R., Biochem. J. 352:601-610(2000).

NCBI and Uniprot Product Information

• NCBI GI #: 261337173
• NCBI GeneID: 4052
• NCBI Accession #: NP_001159738.1
• NCBI GenBank Nucleotide #: NM_001166266.1
• UniProt Accession #: Q14766; P22064; Q53SD8; Q53SF3; Q53SG1; Q59HF7; Q8TD95; A1L3V1
• NCBI Official Full Name: latent-transforming growth factor beta-binding protein 1 isoform 5
• NCBI Official Synonym Full Names: latent transforming growth factor beta binding protein 1
• NCBI Official Symbol: LTBP1
• NCBI Official Synonym Symbols: MGC163161
• NCBI Protein Information: latent-transforming growth factor beta-binding protein 1; LTBP-1; TGF-beta1-BP-1; OTTHUMP00000201218; OTTHUMP00000201281; OTTHUMP00000201282; OTTHUMP00000201676; transforming growth factor beta-1-binding protein 1
• UniProt Protein Name: Latent-transforming growth factor beta-binding protein 1
• Protein Family: Latent-transforming growth factor beta-binding protein
• UniProt Gene Name: LTBP1
• UniProt Entry Name: LTBP1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Uniprot Description

LTBP1: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Belongs to the LTBP family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Chaperone; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p22-p21

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; protein complex; microfibril; extracellular region

Molecular Function: transforming growth factor beta receptor activity; protein binding; transforming growth factor beta binding; microfibril binding; calcium ion binding

Biological Process: extracellular matrix organization and biogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway