Rabbit LRRFIP2 Polyclonal Antibody | anti-LRRFIP2 antibody

LRRFIP2 Antibody

Cat. Num. AAA9402755

• Gene Names: LRRFIP2; HUFI-2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: LRRFIP2; Polyclonal Antibody; LRRFIP2 Antibody; Leucine rich repeat FLI-I interacting protein 2; HUFI-2; anti-LRRFIP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Three isoforms of LRRFIP2 are known to exist; this antibody will recognize all three. LRRFIP2 antibody is predicted to not cross-react with other LRRFIP family members.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 721

• Applicable Applications for anti-LRRFIP2 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 17 amino acid peptide near the carboxy terminus of human LRRFIP2.
• Target Name: LRRFIP2
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of LRRFIP2 in rat colon tissue lysate with LRRFIP2 antibody at (A) 0.5 and (B) 1 ug/mL.)

Related Product Information for anti-LRRFIP2 antibody

The leucine-rich repeat FLI-I-interacting protein 2 (LRRFIP2), like the related protein LRRFIP1, was identified in a yeast two-hybrid system through binding to the LRR domain of human FLI. It can activate the Wnt signaling pathway in cultured cells and is thought to be a component of the Wnt signaling pathway that modulates Wnt signaling through interactions with Disheveled to increase the cellular levels and transcription activity of beta-catenin. LRRFIP2 has recently been characterized as a positive regulator of the TLR4 signaling pathway for activating NF-kB during the early host response to LPS stimulation through binding to the TLR adaptor protein MyD88, and that this interaction with MyD88 is governed by phosphorylation of specific residues in LRRFIP2.

Product Categories/Family for anti-LRRFIP2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 5453726
• NCBI GeneID: 9209
• NCBI Accession #: NP_006300
• NCBI GenBank Nucleotide #: NM_006309.3
• Molecular Weight: 57,394 Da
• NCBI Official Full Name: leucine-rich repeat flightless-interacting protein 2 isoform 1
• NCBI Official Synonym Full Names: leucine rich repeat (in FLII) interacting protein 2
• NCBI Official Symbol: LRRFIP2
• NCBI Official Synonym Symbols: HUFI-2
• NCBI Protein Information: leucine-rich repeat flightless-interacting protein 2
• UniProt Protein Name: Leucine-rich repeat flightless-interacting protein 2
• Protein Family: Leucine-rich repeat flightless-interacting protein
• UniProt Gene Name: LRRFIP2
• UniProt Synonym Gene Names: LRR FLII-interacting protein 2
• UniProt Entry Name: LRRF2_HUMAN

Uniprot Description

LRRFIP2: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 3p22.2

Molecular Function: protein binding; LRR domain binding

Biological Process: Wnt receptor signaling pathway