Rabbit anti-Human, Mouse LPHN3 Polyclonal Antibody | anti-LPHN3 antibody

LPHN3, NT (LPHN3, KIAA0768, LEC3, Latrophilin-3, Calcium-independent alpha-latrotoxin receptor 3, Lectomedin-3) (FITC)

Cat. Num. AAA6316804

• Gene Names: LPHN3; LEC3; CIRL3
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: LPHN3; Polyclonal Antibody; NT (LPHN3; KIAA0768; LEC3; Latrophilin-3; Calcium-independent alpha-latrotoxin receptor 3; Lectomedin-3) (FITC); Lectomedin-3; anti-LPHN3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-LPHN3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: LPHN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-397 amino acids from the N-terminal region of human LPHN3.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(LPHN3 Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the LPHN3 antibody detected the LPHN3 protein (arrow).)

Related Product Information for anti-LPHN3 antibody

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.

Product Categories/Family for anti-LPHN3 antibody

Antibodies; G Protein Receptors

References

Arcos-Burgos, M., et al. Mol. Psychiatry 15(11):1053-1066(2010). Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). Kasperaviciute, D., et al. Brain 133 (PT 7), 2136-2147 (2010): Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 163792198
• NCBI GeneID: 23284
• NCBI Accession #: NP_056051.2
• NCBI GenBank Nucleotide #: NM_015236.4
• UniProt Accession #: Q9HAR2; O94867; Q9NWK5; E9PE04
• Molecular Weight: 164,580 Da
• NCBI Official Full Name: latrophilin-3
• NCBI Official Synonym Full Names: latrophilin 3
• NCBI Official Symbol: LPHN3
• NCBI Official Synonym Symbols: LEC3; CIRL3
• NCBI Protein Information: latrophilin-3; CIRL-3; lectomedin 3; latrophilin homolog 3 (cow); calcium-independent alpha-latrotoxin receptor 3
• UniProt Protein Name: Latrophilin-3
• UniProt Gene Name: LPHN3
• UniProt Synonym Gene Names: KIAA0768; LEC3; CIRL-3
• UniProt Entry Name: LPHN3_HUMAN

NCBI Description

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

Uniprot Description

latrophilin 3: a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; carbohydrate binding

Biological Process: G-protein coupled receptor protein signaling pathway