Western Blot (WB)
(LOXL3 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LOXL3 antibody detected the LOXL3 protein (arrow).)
Rabbit LOXL3 Polyclonal Antibody | anti-LOXL3 antibody
LOXL3 Antibody (C-term)
Western Blot (WB)
(LOXL3 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LOXL3 antibody detected the LOXL3 protein (arrow).)
Western Blot (WB)
(LOXL3 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LOXL3 antibody detected the LOXL3 protein (arrow).)
Immunohistochemistry (IHC)
(LOXL3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LOXL3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(LOXL3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LOXL3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
family. The prototypic member of the family is essential to the
biogenesis of connective tissue, encoding an extracellular
copper-dependent amine oxidase that catalyses the first step in the
formation of crosslinks in collagens and elastin. A highly
conserved amino acid sequence at the C-terminus end appears to be
sufficient for amine oxidase activity, suggesting that each family
member may retain this function. The N-terminus is poorly conserved
and may impart additional roles in developmental regulation,
senescence, tumor suppression, cell growth control, and chemotaxis
to each member of the family. Alternatively spliced transcript
variants of this gene have been reported but their full-length
nature has not been determined.
Sebban, S., et al. Virchows Arch. 454(1):71-79(2009)
Akagawa, H., et al. Hum. Genet. 121 (3-4), 377-387 (2007) :
Lee, J.E., et al. J. Biol. Chem. 281(49):37282-37290(2006)
Peinado, H., et al. EMBO J. 24(19):3446-3458(2005)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
LOXL3: a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Protein type: EC 1.4.3.-; Secreted, signal peptide; Secreted; Oxidoreductase
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: extracellular space; membrane; cytoplasm; extracellular region; nucleus
Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity; scavenger receptor activity
Biological Process: receptor-mediated endocytosis; epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent
Research Articles on LOXL3
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Product Notes
The LOXL3 loxl3 (Catalog #AAA9202045) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 715-744. The LOXL3 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's LOXL3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the LOXL3 loxl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LOXL3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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