Western Blot (WB)
(Western Blot analysis of LOXL1 expression in transfected 293T cell line by LOXL1 polyclonal antibody. Lane 1: LOXL1 transfected lysate (63.1kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human LOXL1 Polyclonal Antibody | anti-LOXL1 antibody
LOXL1 (Lysyl Oxidase Homolog 1, Lysyl Oxidase-like Protein 1, LOL, LOXL) (FITC)
Western Blot (WB)
(Western Blot analysis of LOXL1 expression in transfected 293T cell line by LOXL1 polyclonal antibody. Lane 1: LOXL1 transfected lysate (63.1kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of LOXL1 expression in transfected 293T cell line by LOXL1 polyclonal antibody. Lane 1: LOXL1 transfected lysate (63.1kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016]
Uniprot Description
LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.
Protein type: Secreted; Secreted, signal peptide; Extracellular matrix; EC 1.4.3.-; Oxidoreductase
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: acrosome; basement membrane; extracellular matrix; extracellular region; extracellular space
Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Biological Process: extracellular matrix organization and biogenesis; protein amino acid deamination; response to lipopolysaccharide
Disease: Exfoliation Syndrome
Research Articles on LOXL1
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Product Notes
The LOXL1 loxl1 (Catalog #AAA6384370) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LOXL1 (Lysyl Oxidase Homolog 1, Lysyl Oxidase-like Protein 1, LOL, LOXL) (FITC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LOXL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the LOXL1 loxl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LOXL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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