Immunohistochemistry (IHC)
(Anti-LONP1 / LON antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Rabbit anti-Human LONP1 / LON Polyclonal Antibody | anti-LONP1 / LON antibody
Anti-LONP1 / LON Antibody (aa389-418) IHC-plus
WB (1:1000)
For long term storage store at -20 degree C.
Immunohistochemistry (IHC)
(Anti-LONP1 / LON antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Immunohistochemistry (IHC)
(Anti-LONP1 / LON antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Western Blot (WB)
(LONP1 Antibody western blot of HeLa cell line lysates (35 ug/lane). The LONP1 antibody detected the LONP1 protein (arrow).)
Western Blot (WB)
(LONP1 Antibody western blot of HeLa cell line lysates (35 ug/lane). The LONP1 antibody detected the LONP1 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Uniprot Description
PRSS15: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. Belongs to the peptidase S16 family.
Protein type: RNA-binding; DNA-binding; Mitochondrial; EC 3.4.21.-; Protease
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; membrane; mitochondrial matrix; mitochondrion; nucleoplasm; nucleus
Molecular Function: ADP binding; ATP binding; ATP-dependent peptidase activity; G-quadruplex DNA binding; protein binding; sequence-specific DNA binding; serine-type endopeptidase activity; single-stranded DNA binding; single-stranded RNA binding
Biological Process: aging; chaperone-mediated protein complex assembly; misfolded or incompletely synthesized protein catabolic process; mitochondrial DNA metabolic process; mitochondrial genome maintenance; mitochondrion organization and biogenesis; protein homooligomerization; proteolysis involved in cellular protein catabolic process; response to aluminum ion; response to hormone stimulus; response to hypoxia
Disease: Codas Syndrome
Research Articles on LONP1 / LON
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Product Notes
The LONP1 / LON lonp1 (Catalog #AAA2400139) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-LONP1 / LON Antibody (aa389-418) IHC-plus reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LONP1 / LON can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P (1:100) WB (1:1000). Researchers should empirically determine the suitability of the LONP1 / LON lonp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LONP1 / LON, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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