Rabbit anti-Human LOC129293 Polyclonal Antibody | anti-LOC129293 antibody
LOC129293 (C-Term) Rabbit pAb
NCBI and Uniprot Product Information
Uniprot Description
TRABD2A: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. Belongs to the TIKI family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.-.-; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: integral to plasma membrane
Molecular Function: Wnt-protein binding; metal ion binding; metalloendopeptidase activity
Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; protein amino acid oxidation; metabolic process; proteolysis
Similar Products
Product Notes
The LOC129293 trabd2a (Catalog #AAA8551564) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LOC129293 (C-Term) Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LOC129293 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000. Researchers should empirically determine the suitability of the LOC129293 trabd2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LOC129293, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
