Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human heart using MBS7601046 (LNPEP antibody) at dilution of 1:50)
Rabbit anti-Human LNPEP Polyclonal Antibody | anti-LNPEP antibody
LNPEP Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human heart using MBS7601046 (LNPEP antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human heart using MBS7601046 (LNPEP antibody) at dilution of 1:50)
Western Blot (WB)
(human brain tissue were subjected to SDS PAGE followed by western blot with MBS7601046 (LNPEP antibody) at dilution of 1:800)
Western Blot (WB)
(human brain tissue were subjected to SDS PAGE followed by western blot with MBS7601046 (LNPEP antibody) at dilution of 1:800)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
IRAP: a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described.
Protein type: Protease; EC 3.4.11.3; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q15
Cellular Component: cytoplasmic vesicle membrane; cytosol; extracellular region; integral to plasma membrane; intracellular; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: aminopeptidase activity; metallopeptidase activity; peptide binding; protein binding; zinc ion binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cell-cell signaling; female pregnancy; peptide catabolic process; protein catabolic process; protein polyubiquitination; proteolysis; regulation of blood pressure; signal transduction
Research Articles on LNPEP
Similar Products
Product Notes
The LNPEP lnpep (Catalog #AAA7601046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LNPEP Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LNPEP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the LNPEP lnpep for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LNPEP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
