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Western Blot (WB) (Western blot analysis of anti-Lmx1a Pab in HL60 cell line lysates (35ug/lane). Lmx1a(arrow) was detected using the purified Pab.)

Rabbit anti-Human, mouse Lmx1a Polyclonal Antibody | anti-Lmx1a antibody

Lmx1a Antibody (Center)

Gene Names
Lmx1a; dr; sst; Lmx1.1; dreher
Reactivity
Human, mouse
Applications
Western Blot, ELISA
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
Lmx1a; Polyclonal Antibody; Lmx1a Antibody (Center); LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 11; LMX-11; LIM/homeobox protein LMX1A; anti-Lmx1a antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This Lmx1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human Lmx1a.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
130-159
Sequence Length
382
Applicable Applications for anti-Lmx1a antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
MOUSE
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of anti-Lmx1a Pab in HL60 cell line lysates (35ug/lane). Lmx1a(arrow) was detected using the purified Pab.)

Western Blot (WB) (Western blot analysis of anti-Lmx1a Pab in HL60 cell line lysates (35ug/lane). Lmx1a(arrow) was detected using the purified Pab.)
Related Product Information for anti-Lmx1a antibody
Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.
Product Categories/Family for anti-Lmx1a antibody
References
Mangale,V.S., Science 319 (5861), 304-309 (2008)
Robertson,E.J., Development 134 (24), 4335-4345 (2007)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42857
NCBI Official Full Name
LIM homeobox transcription factor 1-alpha
NCBI Official Synonym Full Names
LIM homeobox transcription factor 1 alpha
NCBI Official Symbol
Lmx1a
NCBI Official Synonym Symbols
dr; sst; Lmx1.1; dreher
NCBI Protein Information
LIM homeobox transcription factor 1-alpha
UniProt Protein Name
LIM homeobox transcription factor 1-alpha
UniProt Gene Name
Lmx1a
UniProt Synonym Gene Names
LMX-1.1
UniProt Entry Name
LMX1A_MOUSE

Uniprot Description

LMX1A: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; Cell development/differentiation; Motility/polarity/chemotaxis

Cellular Component: nucleus

Molecular Function: DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding

Biological Process: axon guidance; central nervous system neuron differentiation; central nervous system development; dentate gyrus development; transcription, DNA-dependent; multicellular organismal development; hippocampus development; neuron differentiation; negative regulation of neuron differentiation; regulation of transcription, DNA-dependent; regulation of gene expression; midbrain development; cerebellum development; brain development; regulation of cell growth

Research Articles on Lmx1a

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Product Notes

The Lmx1a lmx1a (Catalog #AAA9208662) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 130-159. The Lmx1a Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Lmx1a can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Lmx1a lmx1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lmx1a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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