Rabbit LMOD3 Polyclonal Antibody | anti-LMOD3 antibody

LMOD3 Rabbit Polyclonal

Cat. Num. AAA7601042

• Gene Names: LMOD3; NEM10
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: LMOD3; Polyclonal Antibody; LMOD3 Rabbit Polyclonal; anti-LMOD3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 560

• Applicable Applications for anti-LMOD3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Leiomodin 3 (fetal)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS7601042 (LMOD3 Antibody) at dilution of 1:50)

Western Blot (WB)

(human heart tissue were subjected to SDS PAGE followed by western blot with MBS7601042 (LMOD3 antibody) at dilution of 1:1500)

NCBI and Uniprot Product Information

• NCBI GI #: 749502313
• NCBI GeneID: 56203
• NCBI Accession #: NP_001291347.1
• NCBI GenBank Nucleotide #: NM_001304418.1
• Molecular Weight: 40,194 Da
• NCBI Official Full Name: leiomodin-3
• NCBI Official Synonym Full Names: leiomodin 3
• NCBI Official Symbol: LMOD3
• NCBI Official Synonym Symbols: NEM10
• NCBI Protein Information: leiomodin-3
• UniProt Protein Name: Leiomodin-3
• Protein Family: Leiomodin
• UniProt Gene Name: LMOD3
• UniProt Entry Name: LMOD3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the leiomodin family of proteins. This protein contains three actin-binding domains, a tropomyosin domain, a leucine-rich repeat domain, and a Wiskott-Aldrich syndrome protein homology 2 domain (WH2). Localization of this protein to the pointed ends of thin filaments has been observed, and there is evidence that this protein acts as a catalyst of actin nucleation, and is important to the organization of sarcomeric thin filaments in skeletal muscles. Mutations in this gene have been associated as one cause of Nemaline myopathy, as other genes have also been linked to this disorder. Nemaline myopathy is a disorder characterized by nonprogressive generalized muscle weakness and protein inclusions (nemaline bodies) in skeletal myofibers. Patients with mutations in this gene often present with a severe congenital form of the disorder. [provided by RefSeq, Jan 2015]

Uniprot Description

LMOD3: Belongs to the tropomodulin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3p14.1

Cellular Component: M band; striated muscle thin filament

Molecular Function: actin monomer binding; tropomyosin binding

Biological Process: actin filament organization; muscle contraction; myofibril assembly; pointed-end actin filament capping

Disease: Nemaline Myopathy 10