Western Blot (WB)
(Anti-liver Arginase antibody, MBS175738, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Kidney Tissue Lysate )
Rabbit anti-Mouse, Rat liver Arginase Polyclonal Antibody | anti-ARG1 antibody
Anti-liver Arginase antibody
Western Blot (WB)
(Anti-liver Arginase antibody, MBS175738, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Kidney Tissue Lysate )
Western Blot (WB)
(Anti-liver Arginase antibody, MBS175738, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Kidney Tissue Lysate )
Background: ARG1(arginase, live) is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. The isoform encoded by ARG1, referred to as the liver, or A-I, isoform, contributes 98% of the arginase activity in liver but is also present in red cells. Using a rat liver ARG1 cDNA clone to probe a human liver cDNA library, Haraguchi et al.(1987) isolated and characterized a cDNA corresponding to the ARG1 gene. The ARG1 gene is mapped on 6q23.2 and the arginase gene contains 8 exons. By immunologic studies, 90% of the arginase in red blood cell and liver was precipitated by the antibody, whereas only 50% of the arginase in kidney, brain, and the gastrointestinal tract reacted with it. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
NCBI and Uniprot Product Information
NCBI Description
catalyzes the hydrolysis of arginine to ornithine and urea in arginine metabolism; regulates nitric oxide production [RGD, Feb 2006]
Uniprot Description
ARG1: Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - arginine and proline; Hydrolase; EC 3.5.3.1
Cellular Component: extracellular space; mitochondrial outer membrane; neuron projection; cell soma; cytoplasm; nucleus
Molecular Function: manganese ion binding; arginase activity
Biological Process: mammary gland involution; response to peptide hormone stimulus; maternal process involved in pregnancy; response to lipopolysaccharide; female pregnancy; response to vitamin A; response to vitamin E; response to selenium ion; response to methylmercury; response to wounding; response to axon injury; collagen biosynthetic process; aging; response to drug; response to herbicide; response to amino acid stimulus; liver development; response to manganese ion; response to cadmium ion; arginine metabolic process; response to zinc ion; response to steroid hormone stimulus; arginine catabolic process to ornithine; positive regulation of endothelial cell proliferation; urea cycle; response to amine stimulus; lung development
Research Articles on ARG1
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Product Notes
The ARG1 arg1 (Catalog #AAA175738) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-liver Arginase antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's liver Arginase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ARG1 arg1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "liver Arginase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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