Rabbit LIPH Polyclonal Antibody | anti-LIPH antibody

LIPH Rabbit Polyclonal

Cat. Num. AAA7601028

• Gene Names: LIPH; AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: LIPH; Polyclonal Antibody; LIPH Rabbit Polyclonal; anti-LIPH antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 451

• Applicable Applications for anti-LIPH antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Lipase, member H
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas using MBS7601028 (LIPH antibody) at dilution of 1:50)

Western Blot (WB)

(A549 cells were subjected to SDS PAGE followed by western blot with MBS7601028 (LIPH antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 823672616
• NCBI GeneID: 200879
• Molecular Weight: 50,859 Da
• NCBI Official Full Name: LIPH, partial
• NCBI Official Synonym Full Names: lipase H
• NCBI Official Symbol: LIPH
• NCBI Official Synonym Symbols: AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1
• NCBI Protein Information: lipase member H
• UniProt Protein Name: Lipase member H
• Protein Family: Lipase
• UniProt Gene Name: LIPH
• UniProt Synonym Gene Names: LPDLR; MPAPLA1; PLA1B; LIPH; mPA-PLA1 alpha
• UniProt Entry Name: LIPH_HUMAN

NCBI Description

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]

Uniprot Description

LIPH: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPH are the cause of hypotrichosis type 7 (HYPT7); also known as alopecia universalis congenita Mari type. A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. Defects in LIPH are the cause of woolly hair autosomal recessive type 2 (ARWH2). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: EC 3.1.1.-; Secreted, signal peptide; Secreted; Phospholipase

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space; plasma membrane

Molecular Function: heparin binding; phospholipase activity

Biological Process: lipid catabolic process; lipid digestion

Disease: Hypotrichosis 7