Rabbit LINGO1 Polyclonal Antibody | anti-LINGO1 antibody

Rabbit Polyclonal to Human LINGO1

Cat. Num. AAA247006

• Gene Names: LINGO1; LERN1; LRRN6A; UNQ201
• Reactivity: Bovine, Dog, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, Zebrafish; Predicted Reactivity: Bat, Chicken (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: LINGO1; Polyclonal Antibody; Rabbit Polyclonal to Human LINGO1; Anti-LINGO1 Antibody (Internal) IHC-plus; LERN1; LRRN6A; UNQ201; Human LINGO1; anti-LINGO1 antibody

• Host: Rabbit
• Reactivity: Bovine, Dog, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, Zebrafish; Predicted Reactivity: Bat, Chicken (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human LINGO1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 620

• Applicable Applications for anti-LINGO1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (20 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from internal region of human LINGO1.
• Immunogen Type: Synthetic peptide
• Immunogen: LINGO1 antibody was raised against synthetic 17 amino acid peptide from internal region of human LINGO1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Bovine, Dog, Horse, Rabbit, Pig, Stickleback, Zebrafish (100%); Bat, Opossum, Turkey, Chicken, Pufferfish (94%); Xenopus (82%).
• Antigen Modification: Internal
• Preparation and Storage: Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-LINGO1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-LINGO1 antibody

Also known as LRRN6A (leucine-rich repeat neuronal 6A), LINGO1 is a newly discovered gene that is expressed primarily in the central nervous system during early embro development, and may be an essential protein in the development of the nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 50263044
• NCBI GeneID: 84894
• NCBI Accession #: NP_116197.4
• NCBI GenBank Nucleotide #: NM_032808.6
• UniProt Accession #: Q96FE5; Q6NUK3; Q6UXM3; Q6VVG0; Q6VVG1; Q6VVG2; Q8N3K5; Q96K52; D3DW80
• Molecular Weight: 69,146 Da
• NCBI Official Full Name: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a
• NCBI Official Synonym Full Names: leucine rich repeat and Ig domain containing 1
• NCBI Official Symbol: LINGO1
• NCBI Official Synonym Symbols: LERN1; LRRN6A; UNQ201
• NCBI Protein Information: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1
• UniProt Protein Name: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
• Protein Family: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
• UniProt Gene Name: LINGO1
• UniProt Synonym Gene Names: LERN1; LRRN6A
• UniProt Entry Name: LIGO1_HUMAN

Uniprot Description

LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: epidermal growth factor receptor binding

Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development