Rabbit LGR6 Polyclonal Antibody | anti-LGR6 antibody

LGR6 Rabbit Polyclonal

Cat. Num. AAA7600999

• Gene Names: LGR6; GPCR; VTS20631
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Western Blot, Flow Cytometry, Functional Assay
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: LGR6; Polyclonal Antibody; LGR6 Rabbit Polyclonal; FLJ14471; GPCR; VTS20631; anti-LGR6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human, Mouse,Rat; other species are not tested. Please decide the specificity by homology
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 828

• Applicable Applications for anti-LGR6 antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB), Flow Cytometry (FC/FACS)
• Application Notes: WB : 1:200-1:1000; IHC : 1:20-1:200
• Immunogen: leucine-rich repeat-containing G protein-coupled receptor 6
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis using MBS7600999 (LGR6 antibody) at dilution of 1:50)

Western Blot (WB)

(mouse testis tissue were subjected to SDS PAGE followed by western blot with MBS7600999 (LGR6 antibody) at dilution of 1:100)

Related Product Information for anti-LGR6 antibody

Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

NCBI and Uniprot Product Information

• NCBI GI #: 62912474
• NCBI GeneID: 59352
• NCBI Accession #: NP_001017404.1
• NCBI GenBank Nucleotide #: NM_001017404.1
• UniProt Accession #: Q9HBX8; Q5T509; Q5T512; Q6UY15; Q86VU0; Q96K69; Q9BYD7
• Molecular Weight: 104 kDa
• NCBI Official Full Name: leucine-rich repeat-containing G-protein coupled receptor 6 isoform 3
• NCBI Official Synonym Full Names: leucine rich repeat containing G protein-coupled receptor 6
• NCBI Official Symbol: LGR6
• NCBI Official Synonym Symbols: GPCR; VTS20631
• NCBI Protein Information: leucine-rich repeat-containing G-protein coupled receptor 6
• UniProt Protein Name: Leucine-rich repeat-containing G-protein coupled receptor 6
• Protein Family: Leucine-rich repeat-containing G-protein coupled receptor
• UniProt Gene Name: LGR6
• UniProt Entry Name: LGR6_HUMAN

NCBI Description

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

LGR6: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of adult stem cells. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. A marker of a multipotent population of skin stem cells. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane; vesicle

Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cell migration; positive regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway