Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Lymphonodus Tissue; Lane2: Human Liver Tissue.)
Rabbit anti-Human Leukocyte Immunoglobulin Like Receptor Subfamily B Polyclonal Antibody | anti-LILRB2 antibody
Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Polyclonal Antibody
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Lymphonodus Tissue; Lane2: Human Liver Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Lymphonodus Tissue; Lane2: Human Liver Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant LILRB2, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant LILRB2, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Breast Cancer Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Breast Cancer Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
LILRB2: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: cell surface; cytoplasm; extracellular space; integral component of plasma membrane; membrane; plasma membrane
Molecular Function: amyloid-beta binding; cell adhesion molecule binding; inhibitory MHC class I receptor activity; MHC class I protein binding; protein binding; protein complex binding; protein homodimerization activity; protein phosphatase 1 binding; receptor activity
Biological Process: adaptive immune response; cell surface receptor signaling pathway; cell-cell signaling; cellular defense response; Fc receptor mediated inhibitory signaling pathway; heterotypic cell-cell adhesion; immune response; immune response-inhibiting cell surface receptor signaling pathway; learning and/or memory; negative regulation of antigen processing and presentation; negative regulation of calcium ion transport; negative regulation of immune response; negative regulation of postsynaptic density organization; negative regulation of protein metabolic process; negative regulation of T cell proliferation; neutrophil degranulation; positive regulation of interleukin-6 production; positive regulation of long term synaptic depression; positive regulation of protein dephosphorylation; positive regulation of regulatory T cell differentiation; positive regulation of T cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction; regulation of dendritic cell differentiation; regulation of immune response; regulation of long-term synaptic potentiation; signal transduction
Research Articles on LILRB2
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Product Notes
The LILRB2 lilrb2 (Catalog #AAA2032478) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Leukocyte Immunoglobulin Like Receptor Subfamily B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western Blot: 1:50-400 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the LILRB2 lilrb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Leukocyte Immunoglobulin Like Receptor Subfamily B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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