Rabbit anti-Human LAX1 Polyclonal Antibody | anti-LAX1 antibody

LAX1, CT (LAX1, LAX, Lymphocyte transmembrane adapter 1, Linker for activation of X cells, Membrane-associated adapter protein LAX)

Cat. Num. AAA6004812

• Gene Names: LAX1; LAX
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: LAX1; Polyclonal Antibody; CT (LAX1; LAX; Lymphocyte transmembrane adapter 1; Linker for activation of X cells; Membrane-associated adapter protein LAX); Anti -LAX1; anti-LAX1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-LAX1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: LAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-398 amino acids from the C-terminal region of human LAX1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(LAX1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the LAX1 antibody detected the LAX1 protein (arrow).)

Related Product Information for anti-LAX1 antibody

LAX1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.

Product Categories/Family for anti-LAX1 antibody

Antibodies; Abs to Adapter Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 544583539
• NCBI GeneID: 54900
• NCBI Accession #: NP_001269807.1
• NCBI GenBank Nucleotide #: NM_001282878.1
• UniProt Accession #: Q8IWV1; Q6NSZ6; Q9NXB4; B7Z744; J3KP69
• Molecular Weight: 44,085 Da
• NCBI Official Full Name: lymphocyte transmembrane adapter 1 isoform c
• NCBI Official Synonym Full Names: lymphocyte transmembrane adaptor 1
• NCBI Official Symbol: LAX1
• NCBI Official Synonym Symbols: LAX
• NCBI Protein Information: lymphocyte transmembrane adapter 1; linker for activation of x cells; LAT-like membrane associated protein; membrane-associated adapter protein LAX
• UniProt Protein Name: Lymphocyte transmembrane adapter 1
• Protein Family: Lymphocyte transmembrane adapter
• UniProt Gene Name: LAX1
• UniProt Synonym Gene Names: LAX
• UniProt Entry Name: LAX1_HUMAN

Uniprot Description

LAX1: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: Golgi apparatus; membrane; cytoplasm; integral to membrane; plasma membrane; lipid raft

Molecular Function: protein binding; SH2 domain binding; protein kinase binding

Biological Process: antigen receptor-mediated signaling pathway; B cell activation; immunoglobulin secretion; immune response; negative regulation of T cell activation; inactivation of MAPK activity