Rabbit anti-Human LASS3 Polyclonal Antibody | anti-CERS3 antibody

LASS3 Antibody

Cat. Num. AAA9629272

• Gene Names: CERS3; LASS3
• Reactivity: Human
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: LASS3; Polyclonal Antibody; LASS3 Antibody; Ceramide synthase 3; CerS3; CERS3_HUMAN; LAG1 homolog; ceramide synthase 3; LAG1 longevity assurance homolog 3; LASS 3; MGC 27091; anti-CERS3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: LASS3 Antibody detects endogenous levels of total LASS3.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-CERS3 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Tissue Specificity: Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level).
• Function: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor. It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal. differentiation.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-CERS3 antibody

Endoplasmic reticulum membrane; Multi-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 116235446
• NCBI GeneID: 204219
• NCBI Accession #: NP_849164.2
• NCBI GenBank Nucleotide #: NM_178842.3
• UniProt Accession #: Q8IU89; Q8NE64; Q8NEN6
• Molecular Weight: 46 kDa
• NCBI Official Full Name: ceramide synthase 3
• NCBI Official Synonym Full Names: ceramide synthase 3
• NCBI Official Symbol: CERS3
• NCBI Official Synonym Symbols: LASS3
• NCBI Protein Information: ceramide synthase 3; LAG1 homolog, ceramide synthase 3; LAG1 longevity assurance homolog 3
• UniProt Protein Name: Ceramide synthase 3
• Protein Family: Ceramide synthase
• UniProt Gene Name: CERS3
• UniProt Synonym Gene Names: LASS3; CerS3
• UniProt Entry Name: CERS3_HUMAN

NCBI Description

This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Uniprot Description

Function: May be involved in sphingolipid synthesis or its regulation

By similarity.

Subcellular location: Nucleus membrane; Multi-pass membrane protein

Potential.

Sequence similarities: Contains 1 homeobox DNA-binding domain.Contains 1 TLC (TRAM/LAG1/CLN8) domain.