Western Blot (WB)
(staining (0.1ug/ml) of Human Brain (Cerebellum) extracts (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Goat LASP1 Polyclonal Antibody | anti-LASP1 antibody
LASP1, NT (LIM and SH3 Domain Protein 1, LASP-1, Metastatic Lymph Node Gene 50 Protein, MLN 50, MLN50)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA: 1:128,000
Western Blot: 0.1-0.3ug/ml, human brain (cerebellum) and human colon, duodenum, liver and pancreas lysates observed on ~35kD bands
Western Blot (WB)
(staining (0.1ug/ml) of Human Brain (Cerebellum) extracts (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Western Blot (WB)
(staining (0.1ug/ml) of Human Brain (Cerebellum) extracts (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Uniprot Description
Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types
By similarity.
Subunit structure: Interacts with F-actin
By similarity. Interacts with ANKRD54
By similarity. Interacts with KBTBD10. Ref.8
Subcellular location: Cytoplasm › cell cortex
By similarity. Cytoplasm › cytoskeleton
By similarity. Note: Associated with the F-actin rich cortical cytoskeleton
By similarity.
Sequence similarities: Contains 1 LIM zinc-binding domain.Contains 2 nebulin repeats.Contains 1 SH3 domain.
Research Articles on LASP1
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Product Notes
The LASP1 lasp1 (Catalog #AAA647836) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The LASP1, NT (LIM and SH3 Domain Protein 1, LASP-1, Metastatic Lymph Node Gene 50 Protein, MLN 50, MLN50) reacts with Canine, Human, Mouse, Porcine, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LASP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:128,000 Western Blot: 0.1-0.3ug/ml, human brain (cerebellum) and human colon, duodenum, liver and pancreas lysates observed on ~35kD bands. Researchers should empirically determine the suitability of the LASP1 lasp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LASP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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