Western Blot (WB)
(Western blot analysis of extracts from HEK-293 cells, using LAS1L Antibody. The lane on the left was treated with blocking peptide.)
Rabbit LAS1L Polyclonal Antibody | anti-LAS1L antibody
LAS1L Antibody
Gene Names
LAS1L; WTS; Las1-like; dJ475B7.2
Reactivity
Human, Mouse, RatPredicted: Horse
Applications
Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
LAS1L; Polyclonal Antibody; LAS1L Antibody; dJ475B7.2; FLJ12525; FLJ30133; FLJ45274; LAS1 like (S. cerevisiae); Las1 like; LAS1L_HUMAN; Protein LAS1 homolog; Ribosomal biogenesis protein LAS1L; RP3 475B7.2; anti-LAS1L antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Predicted: Horse
Predicted: Horse
Clonality
Polyclonal
Isotype
IgG
Specificity
LAS1L Antibody detects endogenous levels of LAS1L.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
717
Applicable Applications for anti-LAS1L antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
A synthesized peptide derived from human LAS1L.
Fragment
Fab Fragment
Conjugate
Unconjugated
Subcellular Location
Nucleus
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from HEK-293 cells, using LAS1L Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from HEK-293 cells, using LAS1L Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-LAS1L antibody
Description: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Subunit Structure: Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
Similarity: Belongs to the LAS1 family.
Subunit Structure: Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
Similarity: Belongs to the LAS1 family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed: 83 kDa
Predicted: 84 kDa
Predicted: 84 kDa
NCBI Official Full Name
ribosomal biogenesis protein LAS1L isoform 2
NCBI Official Synonym Full Names
LAS1 like, ribosome biogenesis factor
NCBI Official Symbol
LAS1L
NCBI Official Synonym Symbols
WTS; Las1-like; dJ475B7.2
NCBI Protein Information
ribosomal biogenesis protein LAS1L
UniProt Protein Name
Ribosomal biogenesis protein LAS1L
Protein Family
UniProt Gene Name
LAS1L
UniProt Synonym Gene Names
MSTP060
UniProt Entry Name
LAS1L_HUMAN
Research Articles on LAS1L
Similar Products
Product Notes
The LAS1L las1l (Catalog #AAA9611873) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LAS1L Antibody reacts with Human, Mouse, Rat Predicted: Horse and may cross-react with other species as described in the data sheet. AAA Biotech's LAS1L can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the LAS1L las1l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAS1L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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