Rabbit anti-Human LAMA1 Polyclonal Antibody | anti-LAMA1 antibody

LAMA1 Antibody

Cat. Num. AAA7127436

• Gene Names: LAMA1; LAMA; S-LAM-alpha
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: LAMA1; Polyclonal Antibody; LAMA1 Antibody; laminin; alpha 1; anti-LAMA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: Liquid; In Phosphate Buffered Saline, pH 7.4, 0.05% NaN3, and 40% Glycerol

• Applicable Applications for anti-LAMA1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: ELISA: 1:1000-1:5000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide of human LAMA1
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)-Paraffin

(The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using MBS7127436(LAMA1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200))

Immunohistochemistry (IHC)-Paraffin

(The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using MBS7127436(LAMA1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200))

Product Categories/Family for anti-LAMA1 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 38788416
• NCBI GeneID: 284217
• NCBI Accession #: NP_005550.2
• NCBI GenBank Nucleotide #: NM_005559.3
• UniProt Accession #: P25391
• Molecular Weight: 337,084 Da
• NCBI Official Full Name: laminin subunit alpha-1
• NCBI Official Synonym Full Names: laminin, alpha 1
• NCBI Official Symbol: LAMA1
• NCBI Official Synonym Symbols: LAMA; S-LAM-alpha
• NCBI Protein Information: laminin subunit alpha-1; S-LAM alpha; laminin A chain; S-laminin subunit alpha; laminin-3 subunit alpha
• UniProt Protein Name: Laminin subunit alpha-1
• Protein Family: Laminin
• UniProt Gene Name: LAMA1
• UniProt Synonym Gene Names: LAMA; S-LAM alpha
• UniProt Entry Name: LAMA1_HUMAN

NCBI Description

This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]

Uniprot Description

LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18p11.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; laminin-3 complex; laminin-1 complex; extracellular region; basement membrane; intercellular junction

Molecular Function: protein binding; extracellular matrix structural constituent; glycosphingolipid binding; receptor binding

Biological Process: regulation of cell adhesion; axon guidance; extracellular matrix organization and biogenesis; cell surface receptor linked signal transduction; regulation of embryonic development; morphogenesis of an epithelial sheet; establishment of epithelial cell polarity; cell adhesion; regulation of cell migration

Disease: Poretti-boltshauser Syndrome