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Rabbit L Polyclonal Antibody | anti-L antibody

L Antibody, HRP Conjugated

Reactivity
Vesicular Stomatitis Indiana Virus
Applications
ELISA
Purity
>95%
Protein G Purified
Synonyms
L; Polyclonal Antibody; L Antibody; HRP Conjugated; RNA-directed RNA polymerase L; Protein L; Large structural protein; Replicase; Transcriptase; [Includes: RNA-directed RNA polymerase; EC 2.7.7.48; mRNA (guanine-N(7)-)-methyltransferase; EC 2.1.1.56; GDP polyribonucleotidyltransferase; EC 2.7.7.88; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; EC 2.1.1.296)]; anti-L antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Vesicular Stomatitis Indiana Virus
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%
Protein G Purified
Form/Format
Liquid
Sequence Length
2109
Applicable Applications for anti-L antibody
ELISA (EIA)
Immunogen Species
Vesicular Stomatitis Indiana Virus
Immunogen
Recombinant Vesicular stomatitis Indiana virus RNA-directed RNA polymerase L protein (598-784AA)
Conjugate
HRP
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.

NCBI and Uniprot Product Information

NCBI GI #
UniProt Accession #
Molecular Weight
240,943 Da
NCBI Official Full Name
RNA-directed RNA polymerase L
UniProt Protein Name
RNA-directed RNA polymerase L
Protein Family
L5
UniProt Gene Name
L
UniProt Synonym Gene Names
Protein L

Uniprot Description

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both acticities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.

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Product Notes

The L l (Catalog #AAA7114183) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The L Antibody, HRP Conjugated reacts with Vesicular Stomatitis Indiana Virus and may cross-react with other species as described in the data sheet. AAA Biotech's L can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the L l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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