Structure
HSD-016, Inhibitor
HSD-016
Purity
>98% (HPLC)
Synonyms
HSD-016; HSD016; HSD 016; inhibitor
Purity/Purification
>98% (HPLC)
Target
11beta-HSD
Receptor
11beta-HSD
Chemical Name
(R)-1, 1, 1-trifluoro-2-(3-((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)propan-2-ol
SMILES
CC1CN(CCN1S(=O)(=O)C2=CC=CC(=C2)C(C)(C(F)(F)F)O)C3=C(C=C(C=C3)F)C(F)(F)F
Molecular Formula
C21H21F7N2O3S
CAS Number
946396-92-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for HSD-016, inhibitor
HSD-016 (HSD016) is a potent, selective, and efficacious 11beta-HSD1 inhibitor with IC50 of 149 and 530nM for mouse and human 11beta-HSD1, respectively; significantly inhibits the 11beta-HSD1 activity in mice 3T3-L1 adipocytes with IC50 of 362nM; HSD-016 (HSD016) has entered phase I clinical trials for the treatment of diabetes. Diabetes Phase 1 Clinical
Product Categories/Family for HSD-016, inhibitor
References
1. Wan ZK, et al. J Org Chem. 2011 Sep 2; 76 (17):7048-55.
2. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999 (18)30450-3.
2. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999 (18)30450-3.
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Product Notes
The HSD-016 (Catalog #AAA3606778) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HSD-016, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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