Testing Data
(Sample (30 ug of whole cell lysate) A: A549 10% SDS PAGE Primary antibody diluted at 1: 1000)
Rabbit anti-Human KYNU Polyclonal Antibody | anti-KYNU antibody
KYNU antibody
Immunohistochemistry: 1:100-1:500
Testing Data
(Sample (30 ug of whole cell lysate) A: A549 10% SDS PAGE Primary antibody diluted at 1: 1000)
Testing Data
(Sample (30 ug of whole cell lysate) A: A549 10% SDS PAGE Primary antibody diluted at 1: 1000)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded MCF7 xenograft, using KYNU antibody at 1: 500 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded MCF7 xenograft, using KYNU antibody at 1: 500 dilution.)
NCBI and Uniprot Product Information
Uniprot Description
KYNU: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Belongs to the kynureninase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Amino Acid Metabolism - tryptophan; Hydrolase; EC 3.7.1.3
Chromosomal Location of Human Ortholog: 2q22.2
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol
Molecular Function: protein homodimerization activity; kynureninase activity; pyridoxal phosphate binding
Biological Process: anthranilate metabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; tryptophan catabolic process
Disease: Hydroxykynureninuria
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Product Notes
The KYNU kynu (Catalog #AAA9414652) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KYNU antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KYNU can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:500. Researchers should empirically determine the suitability of the KYNU kynu for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KYNU, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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