Rabbit KYNU Polyclonal Antibody | anti-KYNU antibody

KYNU Polyclonal Antibody

Cat. Num. AAA3011644

• Gene Names: KYNU; KYNUU; VCRL2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KYNU; Polyclonal Antibody; KYNU Polyclonal Antibody; Kynureninase; L-kynurenine hydrolase; anti-KYNU antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KYNU polyclonal antibody detects endogenous levels of KYNU protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 465

• Applicable Applications for anti-KYNU antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant full length Human KYNU.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of KYNU polyclonal antibody)

Related Product Information for anti-KYNU antibody

Kynureninase, also known as L-kynurenine hydrolase, is a 465 amino acid cytoplasmic enzyme. Kynureninase is involved in two pathways; the degredation of L-kynurenine and the biosynthesis of the cofactor NAD(+). The main function of kynureninase is to catalyze the cleavage of L-kynurenine into anthranilic acid and of L-3-hydroxykynurenine into 3-hydroxyanthranilic acid, exhibiting a preference for the L-3-hydroxy form. Kynureninase forms a homodimer, uses pyridoxal phosphate as a cofactor and is inhibited by o-methoxybenzoylalanine (OMBA). Kynureninase is widely expressed, with highest levels found in lung, placenta and liver. Deficiency in kynureninase leads to hyperkynureninuria, a disorder characterized by the inability to break down tryptophan to nicotinic acid (vitamin B6). Increased levels of kynureninase activity are observed in systemic and cerebral inflammatory conditions.

NCBI and Uniprot Product Information

• NCBI GI #: 312839880
• NCBI GeneID: 8942
• NCBI Accession #: NP_001186170
• NCBI GenBank Nucleotide #: NP_001186170.1
• UniProt Accession #: Q16719
• Molecular Weight: ~ 52kDa
• NCBI Official Full Name: kynureninase isoform a
• NCBI Official Synonym Full Names: kynureninase
• NCBI Official Symbol: KYNU
• NCBI Official Synonym Symbols: KYNUU; VCRL2
• NCBI Protein Information: kynureninase
• UniProt Protein Name: Kynureninase
• Protein Family: Kynureninase
• UniProt Gene Name: KYNU
• UniProt Entry Name: KYNU_HUMAN

NCBI Description

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]