Goat anti-Human Kv7.3 Polyclonal Antibody | anti-KCNQ3 antibody

Kv7.3 (KCNQ3, Potassium Voltage-gated Channel, KQT-like Subfamily, Member 3, BFNC2, EBN2, KQT-like 3, Potassium Channel Subunit alpha KvLQT3, Potassium Voltage-gated Channel Subfamily KQT Member 3, Voltage-gated Potassium Channel Subunit Kv7.3)

Cat. Num. AAA620703

• Gene Names: KCNQ3; EBN2; BFNC2; KV7.3
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Kv7.3; Polyclonal Antibody; Kv7.3 (KCNQ3; Potassium Voltage-gated Channel; KQT-like Subfamily; Member 3; BFNC2; EBN2; KQT-like 3; Potassium Channel Subunit alpha KvLQT3; Potassium Voltage-gated Channel Subfamily KQT Member 3; Voltage-gated Potassium Channel Subunit Kv7.3); Anti -Kv7.3 (KCNQ3; anti-KCNQ3 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human KCNQ3 at~23kD. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 96.7kD. Species sequence homology: mouse, rat, bovine, pig.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-KCNQ3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:16000; Western Blot: 0.3ug/ml
• Immunogen: Synthetic peptide, C-SDSVWTPSNKPI, from the C-Terminus of human KCNQ3.
• Positive Control: Human Brain (Cerebral Cortex, Amygdala, Hippocampus) lysates
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 monthsat -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-KCNQ3 antibody

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).

Product Categories/Family for anti-KCNQ3 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 124504639
• NCBI GeneID: 3786
• UniProt Accession #: O43525; B4DJY4; E7EQ89
• Molecular Weight: 96,742 Da
• NCBI Official Full Name: KCNQ3 protein
• NCBI Official Synonym Full Names: potassium voltage-gated channel, KQT-like subfamily, member 3
• NCBI Official Symbol: KCNQ3
• NCBI Official Synonym Symbols: EBN2; BFNC2; KV7.3
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 3; potassium channel subunit alpha KvLQT3; voltage-gated potassium channel subunit Kv7.3; potassium channel, voltage-gated, subfamily Q, member 3
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 3
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNQ3
• UniProt Entry Name: KCNQ3_HUMAN

NCBI Description

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011]

Uniprot Description

Kv7.3: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Defects in KCNQ3 are the cause of benign familial neonatal seizures type 2 (BFNS2). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: voltage-gated potassium channel activity; potassium channel activity; delayed rectifier potassium channel activity

Biological Process: axon guidance; synaptic transmission; membrane hyperpolarization; potassium ion transport

Disease: Seizures, Benign Familial Neonatal, 2