Rabbit anti-Mouse KCNQ3 Polyclonal Antibody | anti-KCNQ3 antibody

KCNQ3, CT (KCNQ3, Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv7.3) (APC)

Cat. Num. AAA6312710

• Gene Names: KCNQ3; EBN2; BFNC2; KV7.3
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNQ3; Polyclonal Antibody; CT (KCNQ3; Potassium voltage-gated channel subfamily KQT member 3; KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3) (APC); Voltage-gated potassium channel subunit Kv7.3; anti-KCNQ3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-KCNQ3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNQ3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 650-679 amino acids from the C-terminal region of human KCNQ3.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(KCNQ3 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the KCNQ3 antibody detected the KCNQ3 protein (arrow).)

Related Product Information for anti-KCNQ3 antibody

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).

Product Categories/Family for anti-KCNQ3 antibody

Antibodies; Ion Channel

References

Bailey, S.D., et al. Diabetes Care (2010). In press: Gomez-Posada, J.C., et al. J. Neurosci. 30(27):9316-9323(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Hahn, A., et al. Brain Dev. 31(7):515-520(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4758630
• NCBI GeneID: 3786
• NCBI Accession #: NP_004510.1
• NCBI GenBank Nucleotide #: NM_004519.3
• UniProt Accession #: O43525; A2VCT8; B4DJY4; E7EQ89
• Molecular Weight: 93,599 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily KQT member 3 isoform 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily Q member 3
• NCBI Official Symbol: KCNQ3
• NCBI Official Synonym Symbols: EBN2; BFNC2; KV7.3
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 3
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 3
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNQ3

NCBI Description

This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Description

Kv7.3: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Defects in KCNQ3 are the cause of benign familial neonatal seizures type 2 (BFNS2). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q24.22

Cellular Component: cell surface; integral component of membrane; integral component of plasma membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: calmodulin binding; protein binding; voltage-gated potassium channel activity

Biological Process: membrane hyperpolarization; potassium ion transmembrane transport; regulation of ion transmembrane transport; synaptic transmission

Disease: Seizures, Benign Familial Neonatal, 2