Rabbit anti-Rat, Mouse Kv11.1 Polyclonal Antibody | anti-Kv11.1 antibody

Kv11.1 Rabbit pAb

Cat. Num. AAA8808422

• Gene Names: KCNV2; Kv8.2; RCD3B; KV11.1
• Reactivity: Rat, Mouse
• Synonyms: Kv11.1; Polyclonal Antibody; Kv11.1 Rabbit pAb; LQT2;HERG; anti-Kv11.1 antibody

• Host: Rabbit
• Reactivity: Rat, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: PBS with 0.02% sodium azide and 50% glycerol pH7.4.
• Concentration: 1mg/ml (varies by lot)

• Species: Human
• Immunogen: Synthetic Peptide
• Preparation and Storage: Store at -20 degree C. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of 1) Rat Brain Tissue, 2) Mouse Brain Tissue with KV11.1 Rabbit pAb EA313 diluted at 1:2,000.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using Kv11.1 (EA313)Rabbit pAb diluted at 1:200.)

NCBI and Uniprot Product Information

• NCBI GI #: 19424136
• NCBI GeneID: 169522
• NCBI Accession #: NP_598004.1
• NCBI GenBank Nucleotide #: NM_133497.3
• UniProt Accession #: Q8TDN2; Q5T6X0
• Molecular Weight: 62,459 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily V member 2
• NCBI Official Synonym Full Names: potassium channel, subfamily V, member 2
• NCBI Official Symbol: KCNV2
• NCBI Official Synonym Symbols: Kv8.2; RCD3B; KV11.1
• NCBI Protein Information: potassium voltage-gated channel subfamily V member 2; voltage-gated potassium channel subunit Kv8.2
• UniProt Protein Name: Potassium voltage-gated channel subfamily V member 2
• UniProt Gene Name: KCNV2
• UniProt Entry Name: KCNV2_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv8.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B); also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: voltage-gated potassium channel complex; plasma membrane; integral to membrane

Molecular Function: delayed rectifier potassium channel activity

Biological Process: synaptic transmission; protein homooligomerization

Disease: Retinal Cone Dystrophy 3b