Immunohistochemistry (IHC)
(Immunochemical staining of human KRT6C in human breast carcinoma with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human KRT6C Polyclonal Antibody | anti-KRT6C antibody
Anti-KRT6C Antibody, Rabbit Polyclonal
Gene Names
KRT6C; K6E; KRT6E; PPKNEFD
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
KRT6C; Polyclonal Antibody; Anti-KRT6C Antibody; Rabbit Polyclonal; KRT6C Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-K6E Antibody; Anti-KRT6E Antibody; anti-KRT6C antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human KRT6C
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-KRT6C antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
A synthetic peptide corresponding to the center region of the Human KRT6C
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human KRT6C, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human KRT6C in human breast carcinoma with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KRT6C in human breast carcinoma with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KRT6C in human lung cancer with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human KRT6C in human lung cancer with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-KRT6C antibody
keratin KRT6C is a constituent of the cytoskeleton that maintains epidermal integrity and cohesion. Abnormal expression of KRT6C may affect its structural role in the epidermis. Keratins as fibrous proteins, offer structural integrity to various tissues in providing the functional role of protection or load bearing. Keratins consist of central alpha-helical rod domains that are flanked by non-alpha-helical head and tail domains. keratins have evolutionarily conserved and domain-selectively enriched amino acids including glycine and phenylalanine (epidermal), cysteine and proline (hair), and basic and acidic (simple-type epithelial), which reflect unique functions related to structural flexibility, rigidity and solubility, respectively.
References
Strnad P, et al. (2011) Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins. J Cell Sci 124 (Pt 24): 4221-4232.Kakkar P, et al. (2016) Transient structures of keratins from hoof and horn influence their self association and supramolecular assemblies. Int J Biol Macromol 93 (Pt A): 172-178.Guo Z, et al. (2016) Proteomic profiling reveals candidate markers for arsenic-induced skin keratosis. Environ Pollut 218 34-38.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
60 kDa
NCBI Official Full Name
keratin, type II cytoskeletal 6C
NCBI Official Synonym Full Names
keratin 6C, type II
NCBI Official Symbol
KRT6C
NCBI Official Synonym Symbols
K6E; KRT6E; PPKNEFD
NCBI Protein Information
keratin, type II cytoskeletal 6C; CK-6C; CK-6E; K6C; cytokeratin-6C; cytokeratin-6E; keratin 6E; keratin K6h; type-II keratin Kb12
UniProt Protein Name
Keratin, type II cytoskeletal 6C
Protein Family
UniProt Gene Name
KRT6C
UniProt Synonym Gene Names
KRT6E; CK-6C; CK-6E; K6C
UniProt Entry Name
K2C6C_HUMAN
Uniprot Description
Subunit structure: Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.
Tissue specificity: Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.
Miscellaneous: There are at least six isoforms of human type II keratin-6 (K6).There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Sequence similarities: Belongs to the intermediate filament family.
Similar Products
Product Notes
The KRT6C krt6c (Catalog #AAA8102741) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-KRT6C Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KRT6C can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the KRT6C krt6c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KRT6C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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