Rabbit anti-Mouse Krt6a Polyclonal Antibody | anti-Krt6a antibody

Krt6a, ID (Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6, Keratin, type II cytoskeletal 6A, Cytokeratin-6A, Keratin-6-alpha, Keratin-6A) (AP)

Cat. Num. AAA6314700

• Gene Names: Krt6a; MK6a; mK6[a]; Krt2-6a; Krt2-6c; 2310016L08Rik
• Reactivity: Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Krt6a; Polyclonal Antibody; ID (Krt6a; Ker2; Krt2-6; Krt2-6a; Krt6; Keratin; type II cytoskeletal 6A; Cytokeratin-6A; Keratin-6-alpha; Keratin-6A) (AP); Keratin-6A; anti-Krt6a antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-Krt6a antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: mouse Krt6a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of mouse Krt6a.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Mouse Krt6a Antibody (Center) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Mouse Krt6a antibody detected the Mouse Krt6a protein (arrow).)

Related Product Information for anti-Krt6a antibody

Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins). Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.

Product Categories/Family for anti-Krt6a antibody

Antibodies; Cytokeratin

References

Sehic, A., et al. Eur. J. Oral Sci. 117(2):93-104(2009). Chen, J., et al. J. Invest. Dermatol. 128(2):270-279(2008). Cui, C.Y., et al. Hum. Mol. Genet. 16(21):2583-2590(2007). Gu, L.H., et al. J. Invest. Dermatol. 127(5):1061-1073(2007). Kurek, D., et al. Development 134(2):261-272(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 54607171
• NCBI GeneID: 16687
• NCBI Accession #: NP_032502.3
• NCBI GenBank Nucleotide #: NM_008476.3
• UniProt Accession #: P50446; Q9Z332
• Molecular Weight: 59,335 Da
• NCBI Official Full Name: keratin, type II cytoskeletal 6A
• NCBI Official Synonym Full Names: keratin 6A
• NCBI Official Symbol: Krt6a
• NCBI Official Synonym Symbols: MK6a; mK6[a]; Krt2-6a; Krt2-6c; 2310016L08Rik
• NCBI Protein Information: keratin, type II cytoskeletal 6A; K6A; CK-6A; mK6-alpha; keratin-6A; 60-kDa keratin; cytokeratin-6A; keratin-6-alpha; keratin complex 2, gene 6a; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c
• UniProt Protein Name: Keratin, type II cytoskeletal 6A
• Protein Family: Keratin
• UniProt Gene Name: Krt6a
• UniProt Synonym Gene Names: Ker2; Krt2-6; Krt2-6a; Krt6; CK-6A; mK6-alpha; K6A
• UniProt Entry Name: K2C6A_MOUSE