Rabbit anti-Mouse, Rat KOR-1 Polyclonal Antibody | anti-KOR-1 antibody

KOR-1 Antibody

Cat. Num. AAA9503558

• Gene Names: Oprk1; KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
• Reactivity: Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: KOR-1; Polyclonal Antibody; KOR-1 Antibody; Kappa-type opioid receptor; MSL-1; OPRK; OPRK1; ROR-D; anti-KOR-1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Specificity: KOR-1 Antibody detects endogenous levels of total KOR-1 protein.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 380

• Applicable Applications for anti-KOR-1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50~1:100; ELISA: 1:5000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from mouse KOR-1.
• Immunogen Range: 331-380
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KOR-1 Antibody. The picture on the right is blocked with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 324120905
• NCBI GeneID: 18387
• NCBI Accession #: NP_001191300.1
• NCBI GenBank Nucleotide #: NM_001204371.1
• UniProt Accession #: P33534
• Molecular Weight: 42 kDa
• NCBI Official Full Name: kappa-type opioid receptor isoform 1
• NCBI Official Synonym Full Names: opioid receptor, kappa 1
• NCBI Official Symbol: Oprk1
• NCBI Official Synonym Symbols: KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
• NCBI Protein Information: kappa-type opioid receptor
• UniProt Protein Name: Kappa-type opioid receptor
• UniProt Gene Name: Oprk1
• UniProt Synonym Gene Names: K-OR-1; KOR-1

NCBI Description

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Uniprot Description

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.