Western Blot (WB)
(Western Blot analysis of KMO expression in transfected 293T cell line using MBS6009502. Lane 1: KMO transfected lysate (44.77kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human KMO Polyclonal Antibody | anti-KMO antibody
KMO (Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase, DJ317G22.1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of KMO expression in transfected 293T cell line using MBS6009502. Lane 1: KMO transfected lysate (44.77kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of KMO expression in transfected 293T cell line using MBS6009502. Lane 1: KMO transfected lysate (44.77kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
Uniprot Description
KMO: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Mitochondrial; EC 1.14.13.9; Membrane protein, multi-pass; Membrane protein, integral; Amino Acid Metabolism - tryptophan
Chromosomal Location of Human Ortholog: 1q42-q44
Cellular Component: mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane; cytosol
Molecular Function: FAD binding; NAD(P)H oxidase activity; kynurenine 3-monooxygenase activity
Biological Process: anthranilate metabolic process; NAD metabolic process; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; tryptophan catabolic process; response to salt stress
Research Articles on KMO
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Product Notes
The KMO kmo (Catalog #AAA6009502) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The KMO (Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase, DJ317G22.1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KMO can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the KMO kmo for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MDSSVIQRKK VAVIGGGLVG SLQACFLAKR NFQIDVYEAR EDTRVATFTR GRSINLALSH RGRQALKAVG LEDQIVSQGI PMRARMIHSL SGKKSAIPYG TKSQYILSVS RENLNKDLLT AAEKYPNVKM HFNHRLLKCN PEEGMITVLG SDKVPKDVTC DLIVGCDGAY STVRSHLMKK PRFDYSQQYI PHGYMELTIP PKNGDYAMEP NYLHIWPRNT FMMIALPNMN KSFTCTLFMP FEEFEKLLTS NDVVDFFQKY FPDAIPLIGE KLLVQDFFLL PAQPMISVKC SSFHFKSHCV LLGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFSNDLSL CLPVFSRLRI PDDHAISDLS MYNYIEKNME RFLHAIMPST FIPLYTMVTF SRIRYHEAVQ RWHWQKR. It is sometimes possible for the material contained within the vial of "KMO, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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