Rabbit anti-Human, Mouse KLRK1 Polyclonal Antibody | anti-KLRK1 antibody

KLRK1 (KLR, CD314, NKG2D, NKG2-D, D12S2489E, Killer Cell Lectin-like Receptor Subfamily K Member 1) (MaxLight 550)

Cat. Num. AAA6447467

• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: KLRK1; Polyclonal Antibody; KLRK1 (KLR; CD314; NKG2D; NKG2-D; D12S2489E; Killer Cell Lectin-like Receptor Subfamily K Member 1) (MaxLight 550); anti-KLRK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human KLRK1. Species Crossreactivity: Mouse
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-KLRK1 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human KLRK1.
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-KLRK1 antibody

Antibodies; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 315221164
• NCBI GeneID: 100528032
• NCBI Accession #: NP_001186734.1
• NCBI GenBank Nucleotide #: NM_001199805.1
• UniProt Accession #: P26718; Q9NR41; A8K7K5; A8K7P4
• Molecular Weight: 25,274 Da
• NCBI Official Full Name: NKG2-D type II integral membrane protein
• NCBI Official Symbol: KLRC4-KLRK1
• NCBI Protein Information: NKG2-D type II integral membrane protein; NK cell receptor D; NKG2-D-activating NK receptor; killer cell lectin-like receptor subfamily K member 1
• UniProt Protein Name: NKG2-D type II integral membrane protein
• Protein Family: NKG2-D type II integral membrane protein
• UniProt Gene Name: KLRK1
• UniProt Synonym Gene Names: D12S2489E; NKG2D
• UniProt Entry Name: NKG2D_HUMAN

NCBI Description

This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]

Uniprot Description

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: regulation of immune response; T cell costimulation; natural killer cell activation; innate immune response; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; signal transduction