Rabbit anti-Human KLRK1 Polyclonal Antibody | anti-KLRK1 antibody
KLRK1 Rabbit pAb
Reactivity
Human
Applications
Immunofluorescence
Purity
Affinity Purified
Synonyms
KLRK1; Polyclonal Antibody; KLRK1 Rabbit pAb; KLR; CD314; NKG2D; NKG2-D; D12S2489E; anti-KLRK1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purified
Form/Format
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Sequence Length
216
Applicable Applications for anti-KLRK1 antibody
Immunofluorescence (IF)
Application Notes
IF: 1:50-1:200
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KLRK1 (NP_031386.2).
Cellular Localization
Cell Membrane, Membrane
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Related Product Information for anti-KLRK1 antibody
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
NCBI and Uniprot Product Information
NCBI GI #
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
25kDa
NCBI Official Full Name
NKG2-D type II integral membrane protein
UniProt Protein Name
NKG2-D type II integral membrane protein
Protein Family
UniProt Gene Name
KLRK1
UniProt Synonym Gene Names
D12S2489E; NKG2D
UniProt Entry Name
NKG2D_HUMAN
Uniprot Description
KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.2-p12.3
Cellular Component: cell surface; integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; receptor activity; carbohydrate binding
Biological Process: regulation of immune response; T cell costimulation; natural killer cell activation; innate immune response; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; signal transduction
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Product Notes
The KLRK1 klrk1 (Catalog #AAA8548606) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KLRK1 Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KLRK1 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF). IF: 1:50-1:200. Researchers should empirically determine the suitability of the KLRK1 klrk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KLRK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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