Rabbit anti-Human KLRC1 Polyclonal Antibody | anti-KLRC1 antibody

KLRC1 (Killer Cell Lectin-like Receptor Subfamily C Member 1, CD159A, MGC13374, MGC59791, NKG2, NKG2A) (HRP)

Cat. Num. AAA6424113

• Gene Names: KLRC1; NKG2; NKG2A; CD159A
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: KLRC1; Polyclonal Antibody; KLRC1 (Killer Cell Lectin-like Receptor Subfamily C Member 1; CD159A; MGC13374; MGC59791; NKG2; NKG2A) (HRP); anti-KLRC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human KLRC1.
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-KLRC1 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human KLRC1.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of HEK-293 cell lysate using KLRC1 antibody.)

Product Categories/Family for anti-KLRC1 antibody

Antibodies; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4504881
• NCBI GeneID: 3821
• NCBI Accession #: NP_002250.1
• NCBI GenBank Nucleotide #: NM_002259.4
• UniProt Accession #: P26715
• Molecular Weight: 26,314 Da
• NCBI Official Full Name: NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A
• NCBI Official Synonym Full Names: killer cell lectin-like receptor subfamily C, member 1
• NCBI Official Symbol: KLRC1
• NCBI Official Synonym Symbols: NKG2; NKG2A; CD159A
• NCBI Protein Information: NKG2-A/NKG2-B type II integral membrane protein; NK cell receptor A; C-lectin type II protein; natural killer cell lectin; natural killer group protein 2; NKG2-1/B activating NK receptor; NKG2-A/B-activating NK receptor; CD159 antigen-like family member A
• UniProt Protein Name: NKG2-A/NKG2-B type II integral membrane protein
• UniProt Gene Name: KLRC1
• UniProt Synonym Gene Names: NKG2A
• UniProt Entry Name: NKG2A_HUMAN

NCBI Description

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

NKG2A: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; transmembrane receptor activity; carbohydrate binding

Biological Process: regulation of immune response; cell surface receptor linked signal transduction