Rabbit anti-Human, Mouse KLF7 Polyclonal Antibody | anti-KLF7 antibody

Anti-KLF7 Antibody, Rabbit Polyclonal

Cat. Num. AAA8102256

• Gene Names: KLF7; UKLF
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: KLF7; Polyclonal Antibody; Anti-KLF7 Antibody; Rabbit Polyclonal; KLF7 Antibody; Rabbit PAb; Antigen Affinity Purified; Kruppel-like factor 7 (ubiquitous); Anti-UKLF Antibody; anti-KLF7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human KLF7
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-KLF7 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: A synthetic peptide corresponding to the center region of the Human KLF7
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human KLF7, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining KLF7 in human duodenum with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining KLF7 in human testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining KLF7 in mouse testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-KLF7 antibody

KLF7 (Kruppel Like Factor 7) is a Protein Coding gene. KLF7 is a member of the KLF family of zinc-finger transcription factors and was the first KLF cloned using complementary DNA and polymerase chain reaction (PCR) techniques with human vascular endothelial cells as a template. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. Besides, KLF7 is known as the ubiquitous Kruppel-like factor, as it is widely expressed in numerous human tissues at low levels. KLF7, a transcription factor that stimulates Schwann cell (SC) proliferation and axonal regeneration after peripheral nerve injury, is a promising therapeutic transcription factor in nerve injury.

NCBI and Uniprot Product Information

• NCBI GI #: 4507829
• NCBI GeneID: 8609
• NCBI Accession #: NP_003700.1
• NCBI GenBank Nucleotide #: NM_003709.3
• UniProt Accession #: O75840; B2RB03
• Molecular Weight: 33,362 Da
• NCBI Official Full Name: Krueppel-like factor 7 isoform 1
• NCBI Official Synonym Full Names: Kruppel-like factor 7 (ubiquitous)
• NCBI Official Symbol: KLF7
• NCBI Official Synonym Symbols: UKLF
• NCBI Protein Information: Krueppel-like factor 7; ubiquitous Kruppel-like transcription factor
• UniProt Protein Name: Krueppel-like factor 7
• Protein Family: Krueppel-like factor
• UniProt Gene Name: KLF7
• UniProt Synonym Gene Names: UKLF
• UniProt Entry Name: KLF7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Description

KLF7: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: nucleus

Molecular Function: DNA binding; zinc ion binding; transcription coactivator activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; axon guidance; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; dendrite morphogenesis