Western Blot (WB)
(KIRREL2 Antibody)
Rabbit KIRREL2 Polyclonal Antibody | anti-KIRREL2 antibody
KIRREL2 Antibody
Gene Names
KIRREL2; NLG1; NEPH3; FILTRIN
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
KIRREL2 antibody is affinity chromatography purified via peptide column.
Synonyms
KIRREL2; Polyclonal Antibody; KIRREL2 Antibody; Kin of irregular chiasm-like protein 2; Kin of IRRE-like protein 2; NEPH3; Nephrin-like protein 3; NLG1; FILTRIN; kin of IRRE like 2 (Drosophila); anti-KIRREL2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
KIRREL2 antibody is human, mouse and rat reactive. At least five isoforms are are known to exist. This antibody is predicted to not cross-react with other members of the KIRREL protein family.
Purity/Purification
KIRREL2 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
708
Applicable Applications for anti-KIRREL2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-p), Immunofluorescence (IF)
Application Notes
KIRREL2 antibody can be used for detection of KIRREL2 by Western blot at 1 - 2 ?g/ml.
Antibody can also be used for immunohistochemistry starting at 5 ?g/mL.
For immunofluorescence start at 20 ?g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples.
All other applications and species not yet tested.
Antibody can also be used for immunohistochemistry starting at 5 ?g/mL.
For immunofluorescence start at 20 ?g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples.
All other applications and species not yet tested.
Conjugate
Unconjugated
Immunogen
KIRREL2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KIRREL2.
The immunogen is located within amino acids 550-600 of KIRREL2
The immunogen is located within amino acids 550-600 of KIRREL2
Buffer
KIRREL2 antibody is supplied in PBS containing 0.02% sodium azide.
Positive Control
Preparation and Storage
KIRREL2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Western Blot (WB)
(KIRREL2 Antibody)
Western Blot (WB)
(KIRREL2 Antibody)
Immunohistochemistry (IHC)
(Immunohistochemistry of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 5 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 5 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 20 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 20 μg/ml.)
Related Product Information for anti-KIRREL2 antibody
KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1). KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2). KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4). Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 64; 70; 78 kDa
Observed: 70 kDa
Observed: 70 kDa
NCBI Official Full Name
kin of IRRE-like protein 2 isoform c
NCBI Official Synonym Full Names
kin of IRRE like 2 (Drosophila)
NCBI Official Symbol
KIRREL2
NCBI Official Synonym Symbols
NLG1; NEPH3; FILTRIN
NCBI Protein Information
kin of IRRE-like protein 2; nephrin-like gene 1; nephrin-like protein 3; kin of irregular chiasm-like protein 2
UniProt Protein Name
Kin of IRRE-like protein 2
Protein Family
UniProt Gene Name
KIRREL2
UniProt Synonym Gene Names
NEPH3
UniProt Entry Name
KIRR2_HUMAN
Uniprot Description
KIRREL2: Belongs to the immunoglobulin superfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.12
Cellular Component: plasma membrane; integral to membrane
Biological Process: cell-cell adhesion; negative regulation of protein amino acid phosphorylation; cell adhesion
Research Articles on KIRREL2
Similar Products
Product Notes
The KIRREL2 kirrel2 (Catalog #AAA153480) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KIRREL2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KIRREL2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-p), Immunofluorescence (IF). KIRREL2 antibody can be used for detection of KIRREL2 by Western blot at 1 - 2 ?g/ml. Antibody can also be used for immunohistochemistry starting at 5 ?g/mL. For immunofluorescence start at 20 ?g/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Researchers should empirically determine the suitability of the KIRREL2 kirrel2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIRREL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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