Rabbit anti-Human KIF7 Polyclonal Antibody | anti-KIF7 antibody
KIF7 Polyclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]
Uniprot Description
Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (). Involved in the regulation of epidermal differentiation and chondrocyte development ().
Research Articles on KIF7
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Product Notes
The KIF7 kif7 (Catalog #AAA9135567) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KIF7 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KIF7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:200 - 1:2000. Researchers should empirically determine the suitability of the KIF7 kif7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: QLDEAIEALD AAIEYKNEAI TCRQRVLRAS ASLLSQCEMN LMAKLSYLSS SETRALLCKY FDKVVTLREE QHQQQIAFSE LEMQLEEQQR LVYWLEVALE RQRLEMDRQL TLQQKEHEQN MQLLLQQSRD HLGEGLADSR RQYEARIQAL EKELGRYMWI NQELKQKLGG VNAVGHSRGG EKRSLCSEGR QAPGNEDELH LAPELLWLSP LTEGAPRTRE ETRDLVHAPL PLTWKRSSLC GEEQGSPEEL RQREA. It is sometimes possible for the material contained within the vial of "KIF7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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