Rabbit KIF2C Polyclonal Antibody | anti-KIF2C antibody

KIF2C Polyclonal Antibody

Cat. Num. AAA3011173

• Gene Names: KIF2C; MCAK; CT139; KNSL6
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KIF2C; Polyclonal Antibody; KIF2C Polyclonal Antibody; ESTM5; KIF 2C; kif2c; KIF2C_HUMAN; Kinesein Family Member 2C; Kinesin family member 2C; kinesin like 6 (mitotic centromere associated kinesin); Kinesin like 6; Kinesin like protein 6; Kinesin like protein KIF2C; Kinesin-like protein 6; Kinesin-like protein KIF2C; KNS L6; KNSL 6; KNSL6; MCAK; MGC11883; Mitotic centromere associated kinesin; Mitotic centromere-associated kinesin; OTTHUMP00000010066; X83316; anti-KIF2C antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KIF2C polyclonal antibody detects endogenous levels of KIF2C protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 725

• Applicable Applications for anti-KIF2C antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant full length Human KIF2C.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of KIF2C polyclonal antibody)

Immunofluorescence (IF)

(Immunofluorescence analysis of U2OS cells, using KIF2C polyclonal antibody)

Related Product Information for anti-KIF2C antibody

The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.

NCBI and Uniprot Product Information

• NCBI GI #: 166795250
• NCBI GeneID: 11004
• NCBI Accession #: NP_006836.2
• NCBI GenBank Nucleotide #: NP_006836.2
• UniProt Accession #: Q99661
• Molecular Weight: ~ 95kDa
• NCBI Official Full Name: kinesin-like protein KIF2C isoform 1
• NCBI Official Synonym Full Names: kinesin family member 2C
• NCBI Official Symbol: KIF2C
• NCBI Official Synonym Symbols: MCAK; CT139; KNSL6
• NCBI Protein Information: kinesin-like protein KIF2C
• UniProt Protein Name: Kinesin-like protein KIF2C
• Protein Family: Kinesin-like protein
• UniProt Gene Name: KIF2C
• UniProt Synonym Gene Names: KNSL6; MCAK
• UniProt Entry Name: KIF2C_HUMAN

NCBI Description

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

KIF2C: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Microtubule-binding; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: kinetochore; microtubule cytoskeleton; kinesin complex; membrane; cytoplasmic microtubule; cytosol; nucleus; chromosome, pericentric region

Molecular Function: centromeric DNA binding; microtubule plus-end binding; protein binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: mitosis; cell proliferation; cell division; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule depolymerization; regulation of chromosome segregation; mitotic cell cycle; blood coagulation; mitotic metaphase plate congression; microtubule-based movement; establishment and/or maintenance of microtubule cytoskeleton polarity