Rabbit anti-Human KIF2A Polyclonal Antibody | anti-KIF2A antibody

KIF2A (Kinesin Heavy Chain Member 2A, Kinesin-like Protein KIF2A, HK2, Kinesin 2, KNS2, M-Kinesin)

Cat. Num. AAA618973

• Gene Names: KIF2A; HK2; KIF2
• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation, Immunofluorescence
• Purity: Serum; Whole antisera
• Synonyms: KIF2A; Polyclonal Antibody; KIF2A (Kinesin Heavy Chain Member 2A; Kinesin-like Protein KIF2A; HK2; Kinesin 2; KNS2; M-Kinesin); Anti -KIF2A (Kinesin Heavy Chain Member 2A; anti-KIF2A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: This antibody is specific for Kif2a. Species Crossreactivity: Reactive to most vertebrate species.
• Purity/Purification: Serum; Whole antisera

• Applicable Applications for anti-KIF2A antibody: Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation.
• Immunogen: Produced by immunizing rabbits with a recombinant segment of the N-terminal domain of the human protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-KIF2A antibody

Kif2a is a kinesin-like motor protein that depolymerizes microtubules. It is found in several vertebrate cell types but is strongly expressed in neuronal cells. In dividing cells it is required for bipolar spindle formation and chromosome segregation. In neuronal cells it is involved in neurite outgrowth.

Product Categories/Family for anti-KIF2A antibody

Antibodies; Abs to Motor Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 148612877
• NCBI GeneID: 3796
• NCBI Accession #: NP_004511.2
• NCBI GenBank Nucleotide #: NM_004520.3
• UniProt Accession #: O00139; Q7Z5I3; Q8N5Q7; A5YM42; A5YM54; B4DY54; D3DW97
• Molecular Weight: 79,955 Da
• NCBI Official Full Name: kinesin-like protein KIF2A isoform 1
• NCBI Official Synonym Full Names: kinesin heavy chain member 2A
• NCBI Official Symbol: KIF2A
• NCBI Official Synonym Symbols: HK2; KIF2
• NCBI Protein Information: kinesin-like protein KIF2A; kinesin-2; OTTHUMP00000123384; OTTHUMP00000197299; OTTHUMP00000197300; OTTHUMP00000221863; Kinesin, heavy chain, 2
• UniProt Protein Name: Kinesin-like protein KIF2A
• Protein Family: Kinesin-like protein
• UniProt Gene Name: KIF2A
• UniProt Synonym Gene Names: KIF2; KNS2
• UniProt Entry Name: KIF2A_HUMAN

NCBI Description

Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]

Uniprot Description

KIF2A: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 5q12-q13

Cellular Component: spindle pole; centrosome; kinesin complex; membrane; spindle microtubule; cytosol

Molecular Function: protein binding; microtubule binding; ATPase activity; motor activity; microtubule motor activity; ATP binding

Biological Process: nervous system development; mitotic spindle organization and biogenesis; metabolic process; cell division; microtubule depolymerization; antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic cell cycle; blood coagulation; cell differentiation; microtubule-based movement

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 3