Western Blot (WB)
(Western blot analysis of KIF16B expression in HEK293T (A) whole cell lysates.)
Rabbit anti-Human KIF16B Polyclonal Antibody | anti-KIF16B antibody
Anti-KIF16B Antibody
Western Blot (WB)
(Western blot analysis of KIF16B expression in HEK293T (A) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of KIF16B expression in HEK293T (A) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Description
Function: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. Ref.9
Subunit structure: Interacts with RAB14
By similarity. Interacts with PTPN21. Ref.11
Subcellular location: Cytoplasm › cytoskeleton
Probable. Early endosome membrane. Note: It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns3P)-binding or via its interaction with RAB14. Ref.9 Ref.13
Tissue specificity: Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level). Ref.9
Domain: The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Ref.9 Ref.13
Post-translational modification: Isoform 4 is ubiquitinated at Lys-685.
Sequence similarities: Belongs to the kinesin-like protein family.Contains 1 FHA domain.Contains 1 kinesin-motor domain.Contains 1 PX (phox homology) domain.
Sequence caution: The sequence BAA90971.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAA90971.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence BAB13416.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAB15530.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAI43062.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI43179.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on KIF16B
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Product Notes
The KIF16B kif16b (Catalog #AAA8307063) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-KIF16B Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KIF16B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the KIF16B kif16b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIF16B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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