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Rabbit KIAA1618 Polyclonal Antibody | anti-KIAA1618 antibody

KIAA1618 antibody

Applications
Western Blot
Synonyms
KIAA1618; Polyclonal Antibody; KIAA1618 antibody; Polyclonal KIAA1618; Anti-KIAA1618; KIAA 1618; KIAA-1618; anti-KIAA1618 antibody
Ordering
 
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For Research Use Only!
Host
Rabbit
Clonality
Polyclonal
Form/Format
Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration
1 mg/ml (varies by lot)
Sequence Length
1063
Applicable Applications for anti-KIAA1618 antibody
Western Blot (WB)
Application Notes
WB: 0.2-1 ug/ml
Biological Significance
The exact function of this protein remains unknown.
Cross-Reactivity
Human
Immunogen
KIAA1618 antibody was raised in rabbit using the N terminal of KIAA1618 as the immunogen
Preparation and Storage
Store at 4 degree C, following reconstitution, aliquot and store at -20 degree C. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-KIAA1618 antibody
Affinity purified rabbit polyclonal KIAA1618 antibody
Product Categories/Family for anti-KIAA1618 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
64,260 Da
NCBI Official Full Name
KIAA1618
UniProt Protein Name
E3 ubiquitin-protein ligase RNF213
UniProt Gene Name
RNF213
UniProt Synonym Gene Names
ALO17; C17orf27; KIAA1554; KIAA1618; MYSTR
UniProt Entry Name
RN213_HUMAN

Uniprot Description

RNF213: Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity. Defects in RNF213 are the cause of susceptibility to Moyamoya disease type 2 (MYMY2). A progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults. A chromosomal aberration involving ALO17 is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALK. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: membrane; cytoplasm; nucleolus

Molecular Function: zinc ion binding; ATPase activity; ubiquitin-protein ligase activity; ligase activity

Biological Process: protein autoubiquitination; protein ubiquitination

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Product Notes

The KIAA1618 rnf213 (Catalog #AAA839109) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's KIAA1618 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 0.2-1 ug/ml. Researchers should empirically determine the suitability of the KIAA1618 rnf213 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIAA1618, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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