Rabbit Khdrbs1 Polyclonal Antibody | anti-Khdrbs1 antibody

Mouse Khdrbs1 Antibody (C-term)

Cat. Num. AAA9208299

• Gene Names: Khdrbs1; p62; p68; Sam68
• Reactivity: Mouse (Predicted Reactivity: Chicken, Human, Rat)
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: Khdrbs1; Polyclonal Antibody; Mouse Khdrbs1 Antibody (C-term); KH domain-containing; RNA-binding; signal transduction-associated protein 1; GAP-associated tyrosine phosphoprotein p62; Src-associated in mitosis 68 kDa protein; Sam68; p21 Ras GTPase-activating protein-associated p62; p68; Khdrbs1 {ECO:0000312|MGI:MGI:893579}; anti-Khdrbs1 antibody

• Host: Rabbit
• Reactivity: Mouse (Predicted Reactivity: Chicken, Human, Rat)
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This Mouse Khdrbs1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-443 amino acids from the C-terminal region of mouse Khdrbs1.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.46 (varies by lot)
• Sequence Positions: 414-443
• Sequence Length: 443

• Applicable Applications for anti-Khdrbs1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: MOUSE
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Mouse Khdrbs1 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Khdrbs1 antibody detected the Khdrbs1 protein (arrow).)

Related Product Information for anti-Khdrbs1 antibody

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.

References

Sette, C., et al. J. Androl. 31(1):66-74(2010)
Maroni, P., et al. Mol. Cell. Endocrinol. 309 (1-2), 26-31 (2009) :
Paronetto, M.P., et al. J. Cell Biol. 185(2):235-249(2009)
Huot, M.E., et al. Mol. Cell. Biol. 29(7):1933-1943(2009)
Rajan, P., et al. BMC Cell Biol. 10, 82 (2009) :

NCBI and Uniprot Product Information

• NCBI GI #: 110626031
• NCBI GeneID: 20218
• NCBI Accession #: NP_035447.3
• NCBI GenBank Nucleotide #: NM_011317.4
• UniProt Accession #: Q60749; Q3U8T3; Q60735; Q7M4N5; Q99M33; A2ACH3; B2KG38
• Molecular Weight: 48371
• NCBI Official Full Name: KH domain-containing, RNA-binding, signal transduction-associated protein 1
• NCBI Official Synonym Full Names: KH domain containing, RNA binding, signal transduction associated 1
• NCBI Official Symbol: Khdrbs1
• NCBI Official Synonym Symbols: p62; p68; Sam68
• NCBI Protein Information: KH domain-containing, RNA-binding, signal transduction-associated protein 1
• UniProt Protein Name: KH domain-containing, RNA-binding, signal transduction-associated protein 1
• Protein Family: KH domain-containing, RNA-binding, signal transduction-associated protein
• UniProt Gene Name: Khdrbs1
• UniProt Synonym Gene Names: Sam68
• UniProt Entry Name: KHDR1_MOUSE

Uniprot Description

KHDRBS1: a nuclear RNA-binding protein. May be involved in slicing and mRNA transport. Associates with src in mitosis. Binds to RNA via a heteronuclear ribonucleoprotein K homology domain. Exerts functionally separable effects on cell proliferation and survival, dependent on its ability to bind specifically to RNA.

Protein type: RNA-binding

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; SH3/SH2 adaptor activity; nucleic acid binding; RNA binding; protein complex binding; poly(U) binding; SH3 domain binding; poly(A) binding

Biological Process: positive regulation of translational initiation; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of signal transduction; positive regulation of RNA export from nucleus; regulation of RNA export from nucleus; negative regulation of transcription, DNA-dependent; cell cycle