Rabbit KDM8 / JMJD5 / FLJ13798 Polyclonal Antibody | anti-KDM8 antibody

Rabbit Polyclonal to Human KDM8 / JMJD5 / FLJ13798

Cat. Num. AAA243786

• Gene Names: KDM8; JMJD5
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: KDM8 / JMJD5 / FLJ13798; Polyclonal Antibody; Rabbit Polyclonal to Human KDM8 / JMJD5 / FLJ13798; Anti-KDM8 / JMJD5 / FLJ13798 Antibody (C-Terminus) IHC-plus; KDM8; FLJ13798; JMJD5; Jumonji domain containing 5; Lysine-specific demethylase 8; Human KDM8; anti-KDM8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human JMJD5
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 416

• Applicable Applications for anti-KDM8 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: JMJD5 antibody can be used for detection of JMJD5 by Western blot at 1-2 ug/ml.
• Target Species: Human
• Immunogen Description: An 18 amino acid peptide from near the carboxy terminus of human JMJD5.
• Immunogen Type: Synthetic peptide
• Immunogen: KDM8 / JMJD5 / FLJ13798 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human JMJD5.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-JMJD5 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of JMJD5 in human liver tissue lysate with JMJD5 antibody at (A) 1 and (B) 2 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 223942014
• NCBI GeneID: 79831
• NCBI Accession #: NP_079049.2
• NCBI GenBank Nucleotide #: NM_024773.2
• UniProt Accession #: Q8N371; Q6VAK5; Q9H8B1; B4DLU9
• Molecular Weight: 50,852 Da
• NCBI Official Full Name: lysine-specific demethylase 8 isoform 2
• NCBI Official Synonym Full Names: lysine (K)-specific demethylase 8
• NCBI Official Symbol: KDM8
• NCBI Official Synonym Symbols: JMJD5
• NCBI Protein Information: lysine-specific demethylase 8; jumonji domain containing 5; jmjC domain-containing protein 5; jumonji domain-containing protein 5
• UniProt Protein Name: Lysine-specific demethylase 8
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM8
• UniProt Synonym Gene Names: JMJD5
• UniProt Entry Name: KDM8_HUMAN

NCBI Description

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

Uniprot Description

JMJD5: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.27; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: nucleus

Molecular Function: metal ion binding; histone demethylase activity (H3-K36 specific); chromatin binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle